Tuesday, 6th February 49th Lorne Conference on Protein Structure and Function 2024

• Protein Ubiquitylation: Mysteries Revealed, Mysteries Remain - Rachel Klevit
• Zinc fingers and the regulation of RING E3 ligase activity   - Catherine L Day
• Multiple deubiquitinases regulate DNA repair by the Fanconi Anemia pathway - Andrew Deans
• Stress signaling at the crossroads of development and disease - Micha Rape

The satellite session is sponsored by 

• Oxidation-triggered aggregation of the cell death regulator caspase-8 - Vanessa K Morris
• QUENCHBODY SINGLE-MOLECULE STUDIES - Conall Mc Guinness
• Using nanobodies to improve drug delivery across the blood-brain barrier - Gabby Watson
• Differential dimerisation of DBHS proteins as a route to controlling biomolecular condensation in the cell - Andrew C Marshall
• Exploiting tau ultrastructural polymorphism towards improved diagnostic biomarkers for Chronic Traumatic Encephalopathy (CTE).   - Joanna L New
• Regulation of PEAK family pseudokinase signalling by 14-3-3 - Michael J Roy
•  Conformational states adopted by rotorless F₁-ATPase during its hydrolysis cycle - Meghna Sobti
• Cryo-EM reveals novel drug binding modes at GPCRs - Wessel AC Burger

• Rapid endo-lysosomal turnover of CTLA4 is governed by reversible ubiquitylation and a complex chain architecture - Sylvie Urbé
• USP10—mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer - Pieter Eichhorn
• Double trouble—regulation of ubiquitination by DDD complexes - Peter D Mace
• A collective perspective on E3 ligases - Ngee Kiat (Jake) Chua
• Multifaceted aspects of ubiquitin biology control mitophagy and pexophagy - Michael Clague

The satellite session is sponsored by 

• C-degron pathways guard the fidelity of proteome - Hsueh-Chi Sherry Yen
• Accelerating PROTAC discovery - Jeyan Osman
• Oligomeric remodelling by molecular glues revealed using native mass spectrometry and mass photometry  - Xiaojing Huang
• Development of a Sensitive Kinetic FRET-Based Assay for the Study of HECT E3 Ubiquitin Ligase Inhibition by Small Molecules - Amanda R Brown
• Development of Tools for the Targeted Degradation of GPCRs - Manuela Jorg

The satellite session is sponsored by 

• Oxidant-driven amyloid fibril formation of the human tumour suppressor protein p18^INK4c - Emilie M. Hamzah
• Designing proteins by solving constraints on a quantum computer - Vladimir Morozov
• Accelerating protein molecular dynamics using machine learning - Vladimir Morozov
• GPCRtm: a machine learning-based method for predicting the impact of mutations on G protein-coupled receptor stability - Joao Velloso
• ChuA from pathogenic Escherichia coli selectively acquires heme from host haemoglobin - Daniel R. Fox
• The mechanism of USP16’s interaction with the H2AK119 ubiquitinated nucleosome  - Jack JA Alexandrovics
• Elucidating the structure and function of a novel endolysin for use as an antimicrobial agent against Pseudomonas aeruginosa - Mackenzie Aitken
• Host-Microbial Interactions: The Gut Microbiome & Coeliac Disease - Peter Prendergast
• Structural insights into the bacterial outer-membrane transporter PqqU and how it scavenges PQQ from the environment - Fabian Munder
• Elucidating the Role of an Austropuccinia psidii Effector Protein During Myrtle Rust Infection - Jovarn Sullivan
• A biochemical description of UspN and its function in the metabolism of Pseudomonas aeruginosa - Adrian Smith-Beech
• Exploring Luminescent Nanomaterials for Protein Adhesion - Rihards Ruska
• Analysing non-proteinaceous ubiquitination by mass spectrometry - Marco Jochem
• Identifying and targeting novel E3 ubiquitin ligases in cancer - Tamer Aly
• Small molecule inhibition of the deubiquitinase USP9X - Philipp Schenk
• Structural Characterization of Full-Length Human RAD52 using Cryo-EM: Towards its mechanism of action - Jhonnatan Reales-Gonzalez
• Structural and pharmacological validation of allosteric sites at the M₅ Muscarinic acetylcholine receptor – a target for CNS disorders - Bhavika Rana
• Pro-inflammatory Conformational Changes in C-reactive Protein Caused by Misfolded Proteins - Abhishek Roy
• Illuminating the regulation of the dark kinase PSKH1  - Luke M McAloon
• Determining the structure of the Karposi’s sarcoma-associated herpes virus Bcl-2 protein - Benjamin Espinoza
• EFG-CS: Predicting Chemical Shifts from Amino Acid Sequences with Protein Structure Prediction Using Machine Learning and Deep Learning Models - Xiaotong Gu
• Lost in translation: RNF14 tags translation factors during ribosomal stalling to prevent dysfunctional protein synthesis - Sarah Trevelyan
• The substrate transport cycle of Organic Cation Transporter 1 - Yi Cheng Zeng
• OCT4 to identify colorectal cancer stem cells and therapeutic targets - REEM ALHULAIS
• Do BET bromodomain proteins regulate chromatin remodeling? - Andrea Daners
• Exploring protein interactions between environmental Klebsiella and the bacteriophages that recognize them - Alex S. Hall
• Looking deeper into outer membrane porin loss and resistance to β-lactam drugs including carbapenems in Klebsiella pneumoniae. - Jiahui Li
• Towards structural determination of Relaxin receptor [RXFP1] - Theingi (Tiffany) Myint
• Uncovering the Molecular Mechanism of Lectin-Like Bacteriocins from Pseudomonas spp. Targeting BAM to Slam the Door on AMR - Imogen G Samuels
• Peering Into the Unknown: Unveiling an Uncharacterised Virus (ThV) via AlphaFold - RAPHAEL CABALLES
• Structural studies of recently identified Bacteroides fragilis cholesterol-dependent cytolysin-like (CDCL) proteins. - Riya Joseph
• Azaca: a novel widespread antiphage defence system - Giovanni Leandri
• Split degron system enables the conditional degradation, localisation and interactomes of two proteins     - Laura Corso
• A group of temperate bacteriophages equip their Klebsiella hosts with potent interbacterial weapons - Sally Byers
• The Interplay Between Topology, Supercoiling, and DNA Damage at the Single-Molecule Level - Elise M Wilkinson
• Structural characterization of the Escherichia coli primosome - Muhammad Zahir Siddiqui
• Unravelling Herpesvirus DNA Annealing: Cryo-EM Structure of BALF2 - Jordan Nicholls
• Structural basis of clinical candidate Xanomeline at muscarinic acetylcholine receptors - Mahmuda Yeasmin
• Identifying Phospholipid Scramblase 1 (PLSCR1) as a novel NEDD4-2 target in the kidney - Meriam MS Shabbar
• Defining the interaction between the transcriptional regulator SpNanR and DNA through mutational analysis. - Ashleigh S. Johns
• Developing phage depolymerase enzymes to disarm Klebsiella pneumoniae - Daniel E Williams
• Getting ‘ϕψχal’ with proteins: minimum message length inference of joint distributions of backbone and sidechain dihedral angles - Piyumi R Amarasinghe Baragamage
• Assessing the Validity of Leucine Zipper Constructs Produced in AlphaFold2. - Isobel S J Mitic
• Towards the Cryo-EM Structures of Viral Annealase Proteins - Lucy J Fitschen
• Understanding the molecular pathway of SARM1 mediated axon degeneration - Forhad Saikot
• The elusive pore-forming mechanism of the Yersinia entomophaga toxin complex - Solace Roche
• Hidden Allostery in 14-3-3 Proteins Orchestrated By ATP - Priyanka Bagdiya
• Understanding the role of a clostridial sporulation protein in antibiotic resistance - Clara E Bate
• Mechanism of DNA binding by the FANCM translocase - Lara Abbouche
• The unique N-terminal region of Mycobacterium tuberculosis sigma factor A plays a dominant role in the essential function of this protein - Debashree Behera
• Single-Molecule Exploration of Genomic Maintenance at G-Quadruplexes - Nicholas Kusi-Appauh
• Identification of Rab GTPase interacting proteins using AlphaFold2 - Denaye N Eldershaw
• Apo-Calmodulin binds to the HECT Ubiquitin E3 Ligase UBE3C via its N-terminal IQ Motif - Emily G Schaffter
• Structural impacts of small molecule drugs targeting the ankyrin repeat oncoprotein gankyrin - Taylor M. Laflamme
• Characterizing the physiology and composition of the diatom pyrenoid in Phaeodactylum tricornutum - Adam Lee
• Utilising Midbrain Organoids as a Model System for Mitophagy in Parkinsons's Disease  - Catharina Kueng
• Deletion of a deubiquitylating (DUB) enzyme sensitises KRAS-mutant lung adenocarcinoma to T cell mediated killing - Mara Zeissig
• Deubiquitylating enzyme Trabid controls axon growth and guidance - Hoanh Tran

ECR Dinner is inclusive in your registration and available for pre-registered ECR delegates ONLY. 

Spots are still available. If you want to attend the ECR Dinner, please use this link to login to your registration dashboard and add the ticket.

Proudly sponsored by

• My Adventures in the Ribosome - Venki Ramakrishnan

• Investigating the Mechanisms of Substrate Polyspecificity of the RND Transporter MexB using Cryo-EM - Aidan B Grosas
• The lethal precision: How Tpp2 (BinB) specifically targets mosquitoes - Bradley Spicer
• Neuronal cytoplasmic TDP-43 accumulation causes diverse proteomic changes across time in the mouse cortex - Adam Walker
• Decoding AMYR and CTR Activation: Structural Insights for Obesity Therapeutics - Jian-Jun Cao
• The orphan G protein-coupled receptor GPR55 - Sarah Mueller
• Molecular characteriation of HLA-DR11-RQ13 interactions with the CD4+ F13 TCR derived from HIV controllers   - Janesha Maddumage
• Structural insights into the activation and modulation of a class B1 GPCR by small-molecule ligands - Xin Zhang
• A structural understanding of PINK1 stabilisation and activation during mitochondrial damage - Sylvie Callegari
• Interactions between synthetic TM domains in programmable CARs for immunotherapy - Colin Hockings
• The tumour suppressor protein p16^ink4a forms fully redox-controlled, reversible amyloids - Christoph Goebl
• Developing a dry powder formulation biparatopic-Fc nanobody for inhaled delivery with broad neutralisation against SARS-CoV-2 variants of concern. - Phillip Pymm
• A structural analysis of the nsp9 proteins from the coronaviruses SARS CoV-2 and MERS CoV reveals a conserved RNA binding interface - Roland Gamsjaeger
• Dissecting the RIPK3/MLKL necroptotic molecular switch - Katherine Davies
• Improvement in downstream purification process efficiency by removing bottleneck unit operations - Alistair Hurst
• Structural Characterization of Novel Chi-like Phages Infecting Multiple Klebsiella spp - YAN LI
• Fast and efficient purification of cross-linked stabilised samples for structural biology - Jacob S Lewis
• An investigation into the negative allostery of a ribonucleoprotein complex - Esteban A Finol
• LEGO-CSM: Predictive Building Blocks for Constructing Functional Protein Insights - Alex G C de Sá
• Bio21-WEHI Crystallisation Facility: Services - Roxanne P Smith
• Utilising Plant-Based Proteins: Innovative Scaffolds and Micro-carriers for Cell-Based Meat Cultivation   - Rachel Z Bennie
• Directed evolution – one molecule at a time - Lisanne M. Spenkelink
• Unravelling the Molecular Architecture of the Commander Complex. - Michael D Healy
• Transcriptional regulation study by RIL-seq revealed potential fine-tuning events on the outer membrane through the actions of the sRNAs. - Kwok-Jian Goh
• Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in PRC2 - Qi Zhang
• Characterisation of the interaction between the porin OmpK36 and the receptor binding proteins of the bacteriophages NPat and BMac - Cara Press
• Raiding nature’s toolbox to discover novel RNA polymerases from diverse phage - Jenni A Hayward
• Stoichiometric quantification of AMPK phosphorylation sites by label-free mass spectrometry. - Ashley J Ovens
• Advancements in Nano Flow Chromatography: Improving separation efficiency of LC-MS using packed emitter columns. - Yanxiang Meng
• Molecular structure of an axle-less F₁-ATPase - Emily J Furlong
• Interactions and Function of Oleosins within Oil bodies  - Amanda Board
• Structural and molecular basis of choline uptake into the brain by FLVCR2 - Rosemary Cater
• Structure of the complete human TSC:WIPI3 lysosomal recruitment complex - Charles Bayly-Jones
• Unveiling the Mechanisms of E.coli Outer Membrane Composition and Stability - Melissa Webby
• Unveiling the Mechanisms of E.coli Outer Membrane Composition and Stability - Melissa N Webby
• ProsperousPlus: a one-stop and comprehensive platform for accurate protease-specific substrate cleavage prediction and machine-learning model construction - Fuyi Li
• Enhancing PET Degrading Enzymes: A Combinatory Approach - Santana Royan
• Visualize your research – SPR for protein complex formation studies   -