Monday, 5th February 49th Lorne Conference on Protein Structure and Function 2024

• Molecular architecture of the apoptotic pore - Ana J. García-Sáez
• Shield and Shuttle: Nuclear Import Mechanism of Core Histones H2A-H2B - Jenny Jiou
• Switching the conformation of PPARG for better T2DM therapies - Rebecca L Frkic
• Atypical ACADs in mammalian hydroxy-lipid catabolism - Dave Pagliarini

• The molecular details of a novel phosphorylation-dependent interaction between MRN and the SOSS complex - Liza Cubeddu
• The HIV capsid uses karyopherin mimicry to breach the nuclear envelope - David A Jacques
• Extracellular loops of the β-barrel domain mediate rapid folding and function of self-associating autotransporters - Denisse L Leyton
• New insights into mechanisms of activation and cell recognition by bacterial ABC toxins - Michael J Landsberg

Lunch is available for all delegates.

Student Lunch is available for pre-registered students and speakers only.

In addition to delegate lunch in the Convention Centre, special lunch is available to the first 50 attendees. 

• Structural insight into G protein coupling and activation of human Frizzled 5 receptor - Susovan Das
• The role of the ubiquitin proteasome system in the regulation of copper transport proteins - Kyle Lyon
• Regulation of apoptosis by copper and the proteasome in Drosophila melanogaster. - Lauren A Kirn
• Isolation of a non-canonical RNA-binding domain from a bacterial effector that degrades host mRNA. - Joshua von Ameln
• F1F0 ATP synthase from Pseudomonas aeruginosa - Ian-Blaine Reininger-Chatzgiannakis
• Unveiling Candida albicans' Multi-Drug Resistance: A Biophysical and Structural Analysis of its ABC Transporter - Jeeeun Shin
• Towards understanding cellular interpretation of morphogen signals - Laura Z Kreplin
• Targeted Protein Degradation: A Novel Target Deconvolution Method - Chuhui Ms Huang
• The Silent Threat: Genetic Mutations and Cardiotoxicity Risk - Saba Iftkhar
• Visualising the assembly and disassembly dynamics of the bacterial conjugation machinery. - Shubha Udupa
• Assessing Clinical Significance of VUS in Retinopathy-Linked Genes - Diya Prabhuram
• Integrating Mass Spectrometry methods for characterisation of PROTAC-induced ubiquitination architecture - Hao Dong
• AlzDiscovery: a computational tool to identify Alzheimer’s Disease-causing missense mutations using protein structure information - Georgina Parra
• Cryo-EM reveals the molecular basis of P2X1 receptor activation and inactivation - Felix M Bennetts
• How SARS-CoV-2 mutations affect the presentation of spike-derived peptides by HLA molecules - You Min Ahn
• Developing innovative survivin-derived peptide inhibitors targeting caspase-9 - Saharnaz Rafiee
• Analytical ultracentrifugation: From biophysics to the basics - Zachary D Tillett
• Assessing the viability of RAPIDly discovered cyclic peptides as specific binders to the RIPK3 RHIM functional amyloid - Jessica A Buchanan
• Illuminating the Amyloid State of Tumour Suppressor Protein p16ᴵᴺᴷ⁴ᵃ   - Alex D Botha
• Structural Insights into Positive Allosteric Modulation at the M₄ mAChR - Michaela Kaoullas
• Study of molecular interactions of TREM2 in Alzheimer’s disease   - Siddhant Kumar
• The effect of physiological oxidants on the amyloid formation of the tumour suppressor protein p16^INK4a - Briana R Smith
• Systematic evaluation of computational biophysical measurements of missense mutations in the absence of experimental structures - Qisheng Pan
• Structural studies of cell signalling adaptor protein STimulator of INterferon Genes (STING) in complex with small molecule inhibitors - Maria Eleni Georgopoulou
• Identifying the molecular drivers of pathogenic aldehyde dehydrogenase missense mutations in cancer and non-cancer diseases - Qisheng Pan
• The RNA substrate preferences of CRISPR-Cas13 - Roland W Calvert
• Unravelling the functional impact of the zebrafish p16INK4a transition into amyloid fibrils - Aakriti Sethi
• Functional characterization of muscle-specific AMPK - A therapeutic target for type 2 diabetes mellitus - Muhammad Nur Hamizan Bin Khabib
• Unravelling the structural complexity of enveloped bacteriophages and exploring the role of phage proteins in the infection cycle - Somavally Dalvi
• Studying amyloid formation by exploiting the oxidation-inducible properties of the tumour suppressor protein p16^INK4A  - Pierre de Cordovez
• Mitochondrial Sam50 β-Barrel: Folding Pathways and Functional Regulators - Roshika Ravi
• Lipid–regulated assembly pathway and stability of the barrel assembly machinery protein BamA - Anjana George
• Characterization of the structure and dynamics of oral polymicrobial biofilms - Bindusmita Paul
• Investigating the molecular basis of effector delivery through the bacterial Type IV Secretion System - Doulin C Shepherd
• Understanding selective bacterial nutrient uptake through structural and functional analysis - Michael C Newton-Vesty
• Elucidating the mechanism of action of the dynoles, small molecule endocytosis inhibitors - Philip Zhong
• Explore the dark spots in protein data bank - Junjie Xu
• DDMut-PPI: Predicting effects of mutations on protein-protein interactions using graph-based deep learning - Yunzhuo Zhou
• Structural and functional characterisation of MlaD from Acinetobacter baumannii - Jing Zhang
• Influence of proline-rich regions on the structure and function of autotransporters from enteric pathogens - Amina Mustafa
• Single-Molecule Visualisation of Replication-Transcription Conflicts - Nischal Sharma
• Characterisation of the MlaC-MlaD interaction and phospholipid transport in bacterial pathogens - Jiansi Long
• Determining key influences on p16^INK4a amyloid fibril formation via single residue mutations - Shelby G Gray
• Deciphering the molecular mechanism of HOIL-1, an unconventional ubiquitin ligase - Xiangyi(Susie) Wang
• How some of us remain asymptomatic after COVID-19  - Lawton D Murdolo
•  Investigating Palmitoyl-CoA Impact on DRP1 in Mitochondrial Fission - Javaid Jabbar
• Leveraging Native Extremophilic Microbes to Remediate Volatile Sulphur Compound Interactions in Wine - Sarah Manners
• The molecular mechanisms of cellular recognition by ABC toxins   - Nadezhda A Aleksandrova
• A novel quinone-carrying protein mediates the use of atmospheric carbon monoxide as an energy source for bacteria. - Ashleigh Kropp
• Understanding the Mucin-type O-glycan Biosynthesis in Mucosal Diseases - Shiyi Xi
• How would you like to die: oxidation-triggered aggregate formation of the cell death regulator caspase-8 - Abigail J. Schwartfeger
• Towards the structural characterisation of P-Rex proteins  - Gareth D Jones
• Developing nanobodies as subtype-selective α_1A adrenergic receptor tools  - Yiling Yu
• Development of a Model System to Determine the Interaction Between the Protein RIOK3 and Ubiquitin. - Jacqueline J.L Ormsby
• Crystal structure of a glutamate-binding subunit from a TAXI-TRAP transporter - Irene R Antony
• Engineering of a broad-spectrum bioplastic degrading enzyme - Evelin Pandiamakkal

• Profiling a killer: the molecular mechanisms that regulate MLKL activation - Sarah E Garnish
• Structural insights into the activation and modulation of a class B1 GPCR by small-molecule ligands - Xin Zhang
• Calmodulin binds CAMK family kinase, Chk2, via an unconventional mechanism to allosterically inhibit catalytic activity and regulate the cell cycle - Chris R. Horne
• Understanding the molecular recognition mechanism of Bacteroides fragilis glycosphingolipids by Natural Killer T cell receptor - Praveena Thirunavukkarasu

• Unravelling the mechanism of neurotensin recognition by neurotensin receptor 1 - Kazem KA Asadollahi
• Improvement of microbial lipase activity towards short-chain fatty acids through in silico design - Siti Nurbaya Oslan
• Structural and functional characterization of Interleukin-1 receptor 8 - Nada Alenzi
• Structural characterization of the Sr33 innate immune receptor from wheat - Laura Garzon-Flores
• NMR, LCMS and XL-MS to characterise enzymatic activity of plant TIR domains in innate immunity - Mitchell Sorbello
• Structural insights into how the membrane protein TMEM120A interacts with Mechanosenstive Ion Channel Inhibitors - Mayada Mazhar
• The ejectosome of pectobacterium bacteriophage PhiM1 - Alice-Roza Eruera
• oNKo-001: A reduced potency IL-12 Fc fusion protein with enhanced therapeutic index - Marcin Węgrecki
• ­­­Delineating functional dynamics and allosteric activation with rigidity theory and simulations - Adnan Sljoka
• Global structural analysis of the oversized bacteriophage PhiTE - James Hodgkinson-Bean
• Investigating the disaggregation of α-synuclein fibrils by molecular chaperones - Nicola Auld
• Investigating Mechanisms of HSP70 Chaperone Function at the single-molecule level - Bailey Skewes
• Collagen toolbox 2024 - Siew Ling (Shereen) Ong
• Making sense of TTN encoded missense variants - Akshita Kumar
• Molecular Nodes - Brady A Johnston
• Structural insights into membrane docking of the tuberous sclerosis complex (TSC) - Chris Lupton
• Trading Tails: Modulation of Bacteriophage Host Targeting - Rhys A Dunstan
• How is the bacterial flagellar secreted through the Gram-positive S-layer? - Christopher J Stubenrauch
• Learning to walk: the baby steps of an artificial protein walker - Neil O Robertson
• Exploiting the Actin fold to design nanoparticle-forming proteins with controllable assembly and disassembly - Julien Bergeron
• We do know what we don’t know: unlocking archaeal genomes using artificial intelligence. - Rebecca S Bamert
• Harnessing Nature's Toolkit: Deciphering Host-Pathogen Interactions through Structural Biology - Cyntia Taveneau
• Oxidation-induced structural transformation of p16 from monomer to amyloid is reversible by reduction of disulfide-bound dimer intermediates - Sarah G Heath
• Novel affinity chromatography method for purification of recombinant proteins   - Emma Dal Maso
• Structural investigation of allosteric modulation of the delta opioid receptor - Jesse I Mobbs
• Oligobodies: development of scFv-oligonucleotide conjugates for biomolecular target detection at the single-molecule level   - Nirukshan Shanmugam
• Enhancing protein solution scattering studies with the BioSAXS beamline at the Australian Synchrotron - Annmaree K Warrender
• Mapping co-chaperone interactions in the assembly of PI3K-related kinases - Karolin Berneiser
• Cryo-EM structures of the human adenosine A3 receptor in various states - liudi L.Z zhang
• Target Discovery and Drug Development at oNKo-Innate - Richard Berry
• Structural and Functional Characterization of the Hantaan Virus Polymerase Complex - Jeremy R. Keown
• A novel conformation-specific BAK antibody enables assessment of non-activated BAK levels in cancer cells - Michelle S Miller
• QUENCHBODY_V2: A GENERALISABLE IMMUNOSENSOR FOR DETECTING BIOMOLECULES IN THE LAB OR CLINIC - Jordan Cater
• Exploring the sweet side of cannabinoid synthases - Bhuvana K Shanbhag
• Molecular basis for the assembly of yeast SNX-BAR proteins with the Retromer trafficking coat - Brett Collins
• High resolution structure of HIV-1 (O) group capsid protein N-terminal domain in complex with human cyclophilin A - Nan Li
• Insights into the mechanism of a MoxR AAA+ ATPase, the CbbQO-type Rubisco activase - Yi-Chin Tsai
• How do pentatricopeptide repeat proteins (PPR) bind to ssRNA? - Nicholas Marzano
• Bringing the Ends Together: Unveiling the first cryo-EM structure of prokaryotic Ku and decrypting its role in NHEJ synapsis - Joydeep Baral
• Utilising co-products from New Zealand’s hides and skins - Zoheb Akhter