In the field of structural biology, the importance of obtaining the complete structure of a protein cannot be overstated. This is because it determines the activity, stability and interactions of the protein with other molecules. The complete protein structure is not only related to its role in the cell, but also closely related to drug design, disease development, and biological evolution studies However, current methods for protein structure determination have some limitations that hinder their ability to obtain complete structures of proteins that are more consistent with experimental data. In addition, there are a large number of missing fragments of protein structures in the PDB database that may not be determined experimentally for some reason. These missing fragments may affect the understanding of the complete structure and function of the protein, especially when they are located in the active centre or in key regions that interact with other molecules. Due to continuous advances in computer technology and artificial intelligence, algorithms for protein structure determination and prediction have become efficient and sophisticated. However, it is undeniable that these methods are inherently flawed, and their correctness is somewhat limited. In view of these challenges, filling in these missing regions, developing a comprehensive protein structure database and creating a user-friendly website dedicated to complete protein structures could serve as an effective means of supporting researchers, facilitating scientific discovery, and providing valuable structural references for the protein research community.